- "Welcome, CYRUS, to the H.Y.B.R.I.D Database. You have a Level 100 Clearance."
- —Cyrus, entering the H.Y.B.R.I.D Headquarters Supercomputer.
The H.Y.B.R.I.D. Program is a lethal and sinister Program created by fusing Pokemon DNA together. It is run by Team Galaxy', run by Cyrus. The HYBRID Program is run by Grant Rocket, Cyrus's understudy, and co-commander. Grant Rocket made the Slicer, the machine, that when a hundred Particles of DNA are combined with another, a fusion is created. All fusions, due to the ingredients inside the Slicer, are Level 50, and powerful opponents for any Pokemon. The HYBRID has been known as the greatest invention since the Pokeball, but has been compared to many other evil contraptions. The HYBRID Program once got a hold of a Mewtwo's DNA, and Darkrai's, and made the most lethal Hybrid ever. The invention of the Slicer was too hard to control, and was shut down later.